The Croyle Lab

The laboratories of Maria A. Croyle RPh., PhD.
The University of Texas at Austin's College of Pharmacy

Dr Maria A. Croyle RPh., PhD is a Professor of Pharmaceutics at The University of Texas at Austin College of Pharmacy where she has lead a busy research lab in pursuit of a single-dose, long-lasting Adenovirus-based Ebola vaccine, as well as studies in drug metabolism, novel vaccine formulations and other viral vectors.
Her students have come from all over the world to be challenged by the plethora of skill sets represented in such an innovative research environment.


Jul
16
to Jul 18

Irnela Presents Research at Annual Meeting of The Controlled Release Society in Boston, MA

Dr Croyle and Irnela traveled to Boston, MA to attend the annual meeting of The Controlled Release Society.  Irnela won a Graduate Student Travel Award and presented a poster detailing her latest research titled "Stability and Release Profiles of Adenovirus in Thin Films Used in the Development of an Oral Ebola Vaccine".

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Jun
13
1:30pm 1:30pm

Croyle Lab Film Technology Awarded first U.S. Patent

Research that began in 2009 finally completed its long trek through patent approval.  Titled, "Methods for inducing an immune response via buccal and/or sublingual administration of a vaccine", this patent provides a stable legal foundation as we find ourselves approached by more potential investors from the pharmaceutical industry.
U.S. Patent: 9,675,550

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Apr
22
to Apr 26

Kristina Presents Research at Experimental Biology 2017

Kristina was recognized by the American Society of Pharmacology and Experimental Therapeutics for her novel research identifying the role TALEN adapter proteins play in the regulation of hepatic drug metabolism.  She received a graduate student travel award from ASPET to present a poster and oral presentation at the Experimental Biology 2017 conference in Chicago, IL.

Kristina's Abstract: "Tipping the Balance of Hepatic CYP3A4 Activity Through Integrin-Mediated Outside-In and Inside-Out Signaling

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Apr
14
1:30pm 1:30pm

Croyle Lab Members Present Research Posters at Annual CoP Research Day

Each year the University of Texas College of Pharmacy holds a Research Day event to allow students to share their projects with their peers.  This year, the Croyle Lab took this opportunity to present four different aspects of our research in the form of posters.

Christine - "Cinnamon and Spice as Excipients Are Nice: Impact of Flavoring Agents on the Physical Properties of Dissolvable Films"
Irnela - "Stability and Release Profiles of Adenovirus in Thin Films Used in the Development of an Oral Ebola Vaccine"
Kristina - "Are You Up to Date on Your Vaccines?  What You Need to Know About How Common Viruses and Their Vaccines Impact Your Drug Metabolism"
Jocelyne - "An Evaluation of Loading Efficiency of Protein in Thin Dissolvable Films"

Research Day 2017 Website Link

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Apr
12
1:30am 1:30am

Croyle Awarded $75k Janssen Award from J&J Next Gen Supply Chain Quickfire Challenge

Dr Croyle received a grant of $75,000 from the Johnson and Johnson Next Gen Supply Chain Quickfire Challenge and was recognized in front of industry peers for bringing forward a potential solution to key manufacturing and supply chain challenges that addresses the issues of cost and reliability in healthcare supply chains.

Dr Croyle’s winning solution is a physical film that has been shown to protect vaccines at room temperature and may have the same effect on monoclonal antibodies, which could be of great benefit in pharmaceutical Supply Chain. This innovation potentially could eliminate the need for refrigeration of some APIs (active pharmaceutical ingredients) and finished products—allowing for easier, less costly storage and transportation, as well as easier delivery to patients in remote areas across the globe and emerging markets.

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Feb
21
12:30am12:30am

Croyle Lab Film Technology Selected for 2016-2017 Texas Health Catalyst Award

Dr Croyle delivered one of the winning pitches describing the lab's novel film technology.  The presentation titled "Dissolvable Film for Storage, Transport and Delivery of Thermolabile Therapeutics" was selected by a panel of venture capitalists and industry experts for additional funding to help bring the technology to market.

Texas Health Catalyst Award Announcement

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Dec
12
12:00pm12:00pm

Dr Croyle speaks at Tulane University in Louisiana

Dr Croyle presents a seminar at Tulane University and meets with faculty from the Divisions of Microbiology, Immunology, and Veterinary Medicine to discuss possible research collaborations using our latest film-based vaccine technology.
 

Dr. Maria A. Croyle holding a sheet of edible film capable of storing 100's of vaccine doses at room temperature for over a year.

Dr. Maria A. Croyle holding a sheet of edible film capable of storing 100's of vaccine doses at room temperature for over a year.

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Mar
29
to Apr 3

Dr Croyle travels to The University of Helsinki, Finland as Invited Speaker

Dr Croyle was initived to speak at The University of Helsinki, ImmunoViroTherapy Lab, Center for Drug Research (CDR) and Division of Pharmaceutical Biosciences. 
Her talk title: "Development of a Single Dose, Needle-Free Ebola Vaccine: How Pharmaceutical Science Can Solve Globally Challenging Problems."

Dr Croyle also served as an Opponent for the Public Defense of the Doctoral Thesis of Mari Hirvinen. Thesis title: ”Immunological boosting and personalization of oncolytic virotherapies for cancer treatment”. Ph.D. Advisor: Vincenzo Cerullo

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Feb
19
8:00am 8:00am

Croyle Lab Members complete 2016 Austin Marathon and Half Marathon

Dr Croyle continues to inspire others to "go the extra mile" as two her students run the Austin Marathon and the Austin Half Marathon.
Congratulations to Lilian Tran for completing her second Full marathon!  That's 26.2 miles of mostly uphill running on a warm day.

Lilian running the 2016 Austin Marathon

Lilian running the 2016 Austin Marathon

Our graduate student, Kristina Jonsson-Schmunk continues to impress us as she completes her first Half Marathon (pictured here with her husband).

Kristina and her husband showing off their Finisher's medals at the 2016 Austin Marathon.

Kristina and her husband showing off their Finisher's medals at the 2016 Austin Marathon.

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Feb
11
8:00am 8:00am

Croyle Lab Publishes another Paper!

Title: "Integrin Receptors Play a Key Role in the Regulation of Hepatic Cytochrome P450 3A"

Journal: Drug Metabolism and Disposition
Manuscript ID: 10.1124/dmd.115.068874
Author(s): Kristina Jonsson-Schmunk, Piyanuch Wonganan, Jin Huk Choi, Shellie M Callahan, and Maria A Croyle

** NOTE: Figures from this manuscript were selected for use as cover art for the May 2016 issue of the journal.

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Dec
6
to Dec 10

Lilian presents Poster at ASHP’s Midyear Clinical Meeting in New Orleans

Lilian Tran presents a poster of her research at 50th Midyear Clinical Meeting of the American Society of Health System Professionals in New Orleans, Louisiana
The meeting's keynote speakers are former United States President George W. Bush and First Lady Laura Bush, with an attendance of more than 20,000 pharmacy professionals from about 100 countries.

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Nov
2
3:30pm 3:30pm

U.T. awards Croyle "2015 Best Research Paper Award"

Dr Croyle was awarded the 2015 Best Research Paper Award for "A Single Dose Respiratory Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection.
The paper was considered significant and timely, with the publication happening as the Ebola epidemic in West Africa was peaking.
The University of Texas - Research Excellence Awards

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Nov
1
9:00pm 9:00pm

Croyle Lab Features on National Geographic Breakthrough: Pandemics

On November 1, 2015, The National Geographic Channel will premiere a 6 episode series called Breakthrough.  The first episode centers on "Pandemics" and will feature Dr Croyle's research on an Ebola vaccine with a glimpse of some of her current lab members.

http://channel.nationalgeographic.com/breakthrough-series/articles/the-future-of-fighting-pandemics/

Lilian, Irnela, Jason, Dr Croyle, and Kristina had a chance to show off some of the science that happens in our labs.

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Nov
1
1:00pm 1:00pm

Dr Croyle and Stephen Run 2015 New York City Marathon

Dr Croyle was ready to run her 20th marathon when, the day before flying to New York City, Stephen took a wrong step off of a ladder and twisted his knee.  Despite the pain, Stephen insisted that he would run alongside Dr Croyle and complete the race.  Fortunately for him, Dr Croyle dropped back and kept Stephen motivated so that they could finish the 26.2 miles of the New York City Marathon together. 
That's Teamwork!

SnM_Finishers_3_CL.jpg
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Oct
25
to Oct 29

Croyle Lab attends annual AAPS Conference in Orlando, Florida

Several lab members are presenting scientific posters and giving lectures detailing their work in the Croyle Lab.
The American Association of Pharmaceutical Scientists (AAPS) is a professional, scientific organization of approximately 10,000 members employed in academia, industry, government, and other research institutes worldwide. Founded in 1986, AAPS advances the capacity of pharmaceutical scientists to develop products and therapies that improve global health.
AAPS 2015 Meeting and Exposition

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Updated:  July 19, 2017 by SCS