The Croyle Lab

The laboratories of Maria A. Croyle RPh., PhD.
The University of Texas at Austin's College of Pharmacy

Dr Maria A. Croyle RPh., PhD is a Professor of Pharmaceutics at The University of Texas at Austin College of Pharmacy where she has lead a busy research lab in pursuit of a single-dose, long-lasting Adenovirus-based Ebola vaccine, as well as studies in drug metabolism, novel vaccine formulations and other viral vectors.
Her students have come from all over the world to be challenged by the plethora of skill sets represented in such an innovative research environment.

Kristina and another Merck Future Talent intern.

Kristina and another Merck Future Talent intern.

1.      NAME: Kristina Jonsson-Schmunk

2.      DIVISION OR DEPARTMENT: Pharmaceutics

3.      WHAT YOU’RE SPECIFICALLY STUDYING: In Dr. Croyle's lab I am studying how virus infection changes drug metabolism, specifically cytochrome P450 3A4 (CYP3A4). We have shown that adenovirus infection results in a suppression of CYP3A4 and now I am elucidating the underlying mechanism.

4.      INTERNSHIP: Merck Future Talent

5.      DATES YOU WORKED: June 6 - August 26 (12 weeks)

6.      EXPLAIN WHAT YOU DID DURING YOUR INTERNSHIP: I worked on a joint project between PPDM (pharmacokinetics, pharmacodynamics and drug metabolism) and Safety Assessment. My project was to develop an assay to predict idiosyncratic drug-induced liver injury (IDILI) caused by a specific drug metabolite. I used techniques such as flow cytometry and ELISA to develop the assay.

7.      FAVORITE PART OF YOUR INTERNSHIP: I worked independently on my project and the resources at Merck were great. In my 12 weeks I was able to expand my knowledge about flow cytometry and apply this to my project. I presented my work for the entire division and it felt like my research was making a difference.

8.      MOST CHALLENGING PART OF YOUR INTERNSHIP: It took almost 2 weeks before I could get into the lab because I had to take safety classes that I had to wait to be assigned to me. Things move a little bit slower when you work for a big company compared to here at the university, so you just have to be patient.

9.      ADVICE FOR PEOPLE WHO WILL DO AN INTERNSHIP IN THE FUTURE: This is your chance to network. My supervisors arranged meetings with about 20 scientists around the different fields of Merck so that I could learn about the different departments but also have valuable contacts for when I will start applying for jobs. Everyone loved to talk to me and I felt truly inspired by them.

Updated: December 11, 2016 by SCS