The Croyle Lab

The laboratories of Maria A. Croyle RPh., PhD.
The University of Texas at Austin's College of Pharmacy

Dr Maria A. Croyle RPh., PhD is a Professor of Pharmaceutics at The University of Texas at Austin College of Pharmacy where she has lead a busy research lab in pursuit of a single-dose, long-lasting Adenovirus-based Ebola vaccine, as well as studies in drug metabolism, novel vaccine formulations and other viral vectors.
Her students have come from all over the world to be challenged by the plethora of skill sets represented in such an innovative research environment.

Ph.D. Students Supervised

2019-Present 
Madison Davis                                                           
College of Pharmacy – Pharmaceutics Doctoral Graduate Student
Project title: “In Vitro Models for Assessment of Oral Delivery of Vaccines”

2019-Present
Matthew Le
College of Pharmacy – Pharmaceutics      Doctoral Graduate Student
Project title: “
Identification of Large Scale Process Parameters Critical for Film Stabilized Biological Drugs”

2018-2023
Trang Doan
College of Pharmacy – Pharmaceutics Doctoral Degree Awarded: August 2023
Project title: “Evaluation of Recombinant DNA and AAV Stability in a Novel Film Matrix

2015-2020
Irnela Bajrovic
College of Pharmacy – Pharmaceutics      Doctoral Degree Awarded: December 2020
Project title:  "Physical and Chemical Properties of Amorphous Glassy Solids Containing Biologicals"
Irnela was recognized for her work by the AAPS Global Health Focus and The Controlled Release Society and was a recipient of a U.T. Teaching Assistant of the Year Award. She spent the summer of 2018 at the World Health Organization in Geneva, Switzerland and became Chief Scientific Officer at Jurata Thin Film in Houston, Texas.

2013-2017
Kristina Jonsson-Schmunk

College of Pharmacy – Pharmaceutics       Doctoral Degree Awarded: December 2017
Project title:  "Cell Signaling Pathways Altered by Virus Infection that Play a Role in Hepatic Cytochrome P450 Expression and Function"
Kristina was recognized at the 2014 College of Pharmacy’s Research Day where she received an award for the best poster presented by a graduate student. In the summer of 2016 she participated in Merck’s Future Talent Internship program. She is currently a Senior Scientist in the Immunotoxicology Division at Merck in West Point, PA.
 
2010-2013
Ross Phan

College of Pharmacy – Pharmaceutics            Pharm.D./Ph.D. Student
Project title:  "Physical Characterization of Glassy Films Containing Active Vaccine Candidates"
Ross received College of Pharmacy Award for Outstanding Research at the graduation ceremonies in 2013 as she completed the Pharm.D. portion of her degree plan. 
Current Position:  Ross left the graduate program in 2013 to pursue interests as a clinical pharmacist specializing in oncology.
 
2007-2012
Jin Huk Choi

College of Pharmacy – Pharmaceutics     Doctoral Degree Awarded: December 2012
Thesis title:  "Evaluation of the Oral Mucosa as a Site for Protective Immunization Against Ebola Zaire with an Adenovirus 5-Based Vaccine"
In 2012, Jin Huk received a Graduate Student Achievement Award from Pfizer Global Research and Development at the national meeting of the American Association of Pharmaceutical Scientists. He was also recognized at the 2011 College of Pharmacy’s Research Day where he received an award for the best paper presented by a graduate student.
After completing a post-doctoral Fellowship in the lab of Dr. Bruce Beutler, at the University of Texas Southwestern Medical Center, Dallas, TX.
Current Position: Jin Huk accepted a position at the UT Southwestern Center for Genetics of Host Defense as an Assistant Professor in 2020.
 

2005-2010
Joseph Dekker

Molecular and Cellular Biology Program     Doctoral Degree Awarded: August 2010
Thesis title: “Human Adenovirus Serotype 5 Vaccines: Routes of Delivery and Formulations for Successful Immunization”
Current Position:  Director of Immunology, Molecular Templates, Austin, TX.

2004-2010
Piynauch Wonganan

College of Pharmacy – Pharmaceutics     Doctoral Degree Awarded: August 2010
Thesis title:  "A mechanistic study of how adenovirus infection alters the expression and function of hepatic cytochrome P450 3A"
Piyanuch won an award for the best paper presented by a graduate student during the 2008 College of Pharmacy’s Annual Celebration of Research. She was also recognized at the National ASGT meeting for outstanding work by a graduate student.  She presented a talk describing for the first time how adenoviral vectors improve the efficacy of some chemotherapeutic medications.
Current Position:  Piyanuch has attained a faculty position at Chulalongkorn University (Bangkok, Thailand) where she will establish a research core focusing on cancer biology.

2003-2005
Hong Le

College of Pharmacy – Pharmaceutics     Doctoral Graduate Student
Project title:  "Mechanistic Studies of Adenovirus-Mediated Changes in Renal Cytochromes P450"
Hong left the Pharmaceutics program in 2005 to attend dental school.  

2001-2005
Shellie Callahan

College of Pharmacy – Pharmaceutics     Doctoral Degree Awarded: August 2005
Thesis title:  "Recombinant Adenovirus-Mediated Alterations of Hepatic CYP3A2 and 2C11"
Shellie's dissertation was nominated by the College of Pharmacy for the UT Outstanding Dissertation Award.  
Current Position:  Shellie currently holds a position in the Business Development group at CEDRA, Austin, TX and an adjunct faculty appointment in the Department of Biology at the University of Rhode Island.


Masters Students Supervised

2008
Mariko Takakura

Hoshi University, Tokyo, Japan     Masters Degree Awarded: August 2009
Current Position:
Mariko’s work is part of a collaboration between The University of Texas at Austin College of Pharmacy and Hoshi University.  Part of her research training occurred in Japan and part in Austin.  Her project involved looking at phosphorylation patterns of the retinoid X receptor during viral infection in the liver.

2003-2007
Michael Boquet

College of Pharmacy – Pharmaceutics     Masters Degree Awarded: May 2007   
Thesis title:
Optimization of Poly (D-L-Lactide-Co-Glycolide) Microsphere Production for Oral Delivery to Promote Adenovirus Stability and Intestinal Gene Transfer
Current Position:  Michael is currently an Associate Consultant Engineer at Eli Lilly Indianapolis, IN.

2002-2004
Xin Ming
                                                                             
U.T. College of Pharmacy – Pharmaceutics     Masters Degree Awarded: December  2004   
Thesis Title:
  "Development and Validation of a Semi-Quantitative Reverse Transcription Polymerase Chain Reaction Assay to Detect Changes in Hepatic Cytochrome P450 Expression During Adenovirus Infection in the Rat"
Current Position:  Xin received his Ph.D. in Pharmaceutics from the University of North Carolina in 2008. He is currently a Research Assistant Professor at the same institution in the lab of Rudy Juliano.

2000-2001
Anne Vieira

U.T. College of Pharmacy – Pharmaceutics     Masters Degree Awarded: December  2001
Thesis Title: 
"The Suitability of Different Animal Models for Toxicological Assessment of Intravenously Administered Adenoviral Vectors"
Current Position:  Anne enrolled in medical school at NYU in 2006 after working as a research technician at the Dana Farber Cancer Institute.


Post-Doctoral / Research Fellows Supervised

2022    
Paloma Matre
Visiting Scholar, Ph.D. Biochemistry

University of Stavanger, Stavanger, Norway
Project Title: Role of Adjuvant on Thermostability of Vaccines in Film

2021-23
Chris Pavlos
Visiting Scholar, Ph.D. Organic Chemistry

John Hopkins University
Project Title: Process Design for Thin Films Containing Biologics

2018-19
Damaris Keatinge-Clay
Research Fellow, Ph.D. Biology/Immunology

Universidad de Antioquia -Medellín, Colombia
Project Title: Impact of Integrin Expression on Drug Metabolism in the Human Liver

2010-11
Wenwen Shen

Research Fellow, M.S. Veterinary and Biomedical Science
University of Nebraska, Lincoln, NE
Project Title:  "Evaluation of the Immune Response Induced by Novel Nasal Formulations of an Adenovirus-Based Vaccine"

2009-10
Qing-Ri Jin

Postdoctoral Fellow, Ph.D. Pharmacology        
Seoul National University, Seoul, Korea
Project Title:  "Evaluation of the Expression Patterns of Drug Transporters in the Liver and Kidney during Virus Infection"

2009-10
Shailbala Singh

Postdoctoral Fellow, Ph.D. Immunology, Doctor of Veterinary Medicine (DVM)    
Texas A&M University, College of Veterinary Medicine & Animal Husbandry (Ph.D.)
G.B. Pant University of Agriculture and Technology, Pantnagar, Uttranchal, India (DVM)
Project Title: "Development of Targeted Lentiviral Vectors for the Delivery of siRNA sequences to the brain"

2008
Jad Dawson

Research Fellow and Lab Manager, B.S. Psychology
University of Toronto, Ontario, Canada
Project Title:  "Characterization of Virus-Antibody Complexes"

2007-08
Leah Donaldson

Research Fellow and Lab Manager, B.S. Pharmacology
University of California, Santa Barbara
Project Title:  "Characterization of Animal Models for Vaccine Development"

2005
Lucia Imbrici

Postdoctoral Fellow, Ph.D. Immunology
University of Napoli, Napels, Italy
Project Title:  "Production and Characterization of PEGylated Adenoviruses for Pre-Clinical Studies in Non-Human Primates"


Ph.D. Dissertation Committees

2022
Melissa Soto - Doctoral Student
Pharmaceutics Graduate Program
Project Title:
“Use of Bacteriophages Selected by Directed Evolution as Efficient Gene Delivery Vehicles for Cystic Fibrosis”
Advisor: Debayuti Ghosh (Molecular Pharmaceutics and Drug Delivery)



2021
Mae M. Lewis - Doctoral Student
Biomedical Engineering Graduate Program
Project Title:
“Lipid Nanoparticles as a Treatment for Cystic Fibrosis”
Advisor: Debayuti Ghosh (Molecular Pharmaceutics and Drug Delivery)

2019
Heidi F. Oldenkamp - Doctoral Degree Awarded 5/22
Project Title:
“pH-Responsive Hydrogels for the Oral Delivery of High Isoelectric Point Therapeutic Proteins”
Advisor: Nicholas Peppas (Biomedical Engineering)

2018

Wendy Kaichun Xu - Doctoral Degree Awarded 5/22
Project Title: “Cellular trafficking of the MMTV-encoded Rem-CT”
Advisor: Jaqueline Dudley (Microbiology and Molecular Genetics)

2018

Matthew Miller - Doctoral Degree Awarded 12/20                                
Project Title:
“Intestinal Delivery of High Isoelectric Point, High Molecular Weight Proteins”
Advisor: Nichoals Peppas (U.T.A. College of Engineering, Biomedical Engineering)

2018

Rashmi Mohanty - Doctoral Degree Awarded 12/21
Project Title:
“Development of Improved Formulations Designed to Overcome tumor Extracellular Matrix (ECM) transport barrier(s)”
Advisor: Debadyuti Ghosh (U.T.A. Pharmaceutics)

2017-2019

Hairui Zhang - Doctoral Degree Awarded 12/19
Project Title: “PEGylated chitosan nanoparticle-mediated CRISPR-Cas9 delivery for the correction of F508del CFTR for cystic fibrosis”
Advisors: Hugh Smyth and Debadyuti Ghosh (U.T.A. Pharmaceutics)

2016-2019

Jasmim Leal - Doctroal Degree Awarded 12/19
Project Title: “Phage Library Screening as an Important Tool for Understanding How Peptides Facilitate Transport Across the Mucus Barrier and Improve Drug Delivery to Treat Primary Disease and Secondary Bacterial Infections in CF Patients”
Advisors: Hugh Smyth and Debadyuti Ghosh (U.T.A. Pharmaceutics)

2017

Dan Losowyj – candidacy 5/17 - Doctoral Degree Awarded 5/17
Project Title:  “Use of A Standing Wave Optical Trap for Characterization of Assembly Dynamics of Macromolecular Biological Complexes”
Advisor:  Ernst-Ludwig Florin (U.T.A. Department of Physics)

2016- 2019
Angela Wagner -
candidacy 11/16 - Doctoral Degree Awarded 5/19
Project Title:  "Development of Stimuli-Responsive Nanoscale Hydrogels for Tumor- Targeted Drug Delivery"
Advisor:  Nicholas Peppas (U.T.A. Biomedical Engineering)

2016-2019
John Clegg -
candidacy 5/16 - Doctoral Degree Awarded 5/19
Project Title: "Development of Molecularly Imprinted Polymers for Applications in Biomolecule-Targeted Drug Delivery"
Advisor: Nichoals Peppas (U.T.A. College of Engineering, Biomedical Engineering)

2015-2018
Sandhya Gopal -
candidacy 05/15 - Doctoral Degree Awarded 2018
Project Title:  "Elucidating the Function of A Previously Uncharacterized Gene of Murine Cytomegalovirus (MCMV) M72"
Advisor:  Jason Upton (U.T.A. Microbiology and Molecular Genetics)

2015-2018
Alex Croft -
candidacy 04/15 - Doctoral Degree Awarded 8/18
Project Title:  "The Transcriptome of Intestinal Pathogens During Human Infection"
Advisor:  Stephen Trent (U.T.A. Microbiology and Molecular Genetics)

2015-2017
Lindsey Sharpe
- candidacy 03/15 - Doctoral Degree Awarded 5/17
Project Title:  "Multi-Component Biomaterial Platform for Oral Vaccination by Protein-Antigens"
Advisor:  Nicholas Peppas (U.T.A. Chemical Engineering)

2014-2016
Sarena Horava
- candidacy 08/14 - Doctoral Degree Awarded 5/16
Project Title:  "Novel Carriers for Oral Delivery of Hemophiliac Factor IX"
Advisor:  Nicholas Peppas (U.T.A. Chemical Engineering)

2014-2016

Adam Hilterbrand - candidacy 5/14 -  Doctoral Degree Awarded 5/17
Project Title: 
"The Role of M48 Deubiquitinase Activity During Murine Cytomegalovirus Infection"
Advisor:  Jason Upton (U.T.A. Microbiology and Molecular Genetics)

2012-2016
Youngqiang Gou
- candidacy 04/12 - Doctoral Degree Awarded 5/16
Project Title:  "Use of Recombinant Mouse Mammary Tumor Virus for Therapeutic Treatment of Breast Cancer"
Advisor:  Jackie Dudley (U.T.A. Microbiology and Molecular Genetics)


2011-2014
Brittany Needham - Doctoral Degree Awarded 08/14
Project Title: 
"Modulating the Innate Immune Response by Combinatorial Engineering of Endotoxin"
Advisor:  Stephen Trent (U.T.A. Microbiology and Molecular Genetics)

2011-2014
Chun Jung Chen - Doctoral Degree Awarded 05/14
Project Title:
"Biogenesis of SV40 MicroRNA"
Advisor:  Chris Sullivan (U.T.A. Microbiology and Molecular Genetics)

2011-2015
Scott Kerr -
candidacy 04/11 - Doctoral Degree Awarded 4/15
Project Title:  "Investigation Interferon Induced Transmembrane Protein Interactions with Lysosomal Proteases"
Advisor:  George Georgiou (U.T.A. Microbiology and Molecular Genetics)

2010-2011
Shayna McGill
- candidacy 9/10 - Doctoral Degree awarded 08/11
Thesis Title:  "
An Evaluation of the use of Superparamagnetic Iron Oxide Nanoparticles to Overcome Extracellular Barriers to Lung Disease for Drug Delivery"
Advisor:  Hugh Smyth (U.T.A. Pharmaceutics)

2006-2009
Haripriya Sridharan - candidacy 9/06 - Doctoral Degree awarded 04/09
Thesis Title:  "Role(s) of Non-Structural (NS) Protein 1 of Influenza B in Virus Replication"
Advisor:  Robert Krug (U.T.A. Microbiology and Molecular Genetics)

2005-2007
Chad McKee
- candidacy 2/05 - Doctoral Degree awarded 12/07
Thesis Title:
  "The Role of AKT in the Stability of XIAP and Prevention of Germ Cell Apoptosis" Advisor:  John Richburg (U.T.A. Pharmacology)

2001-2004
Shirley Lu - Doctoral Degree awarded 12/04
Thesis Title:
"The Role of Endocrine Factors in the Modulation of Cytochrome P450 by Cyclosporin"
Advisor:  Lane Brunner (U.T.A. Pharmaceutics)

2000-2002
Taekrho Kim - candidacy 5/01 - Doctoral Degree awarded 12/02
Thesis Title:  "The Effect of Lipoprotein Association on Cyclosporine Metabolism and Toxicity in Rats"
Advisor:  Lane Brunner (U.T.A. Pharmaceutics)

2000-2002
Jinrong Liu - candidacy 8/01 - Doctoral Degree awarded 12/02
Thesis Title:  "The Roles of PXR and cAMP in Cyclosporine-Induced CYP3A Alterations"
Advisor:  Lane Brunner (U.T.A. Pharmaceutics)

2000-2002
True Rogers
- candidacy 5/01 - Doctoral Degree awarded 12/02
Thesis Title:  "Design, Development and Investigation of a Novel Cryogenic Spray-Freezing Process to Enhance the Dissolution of Poorly Water Soluble Drugs"
Advisor:  Robert O. Williams (U.T.A. Pharmaceutics)


M.S. Thesis Committees

2006
Yuvban Wu - Degree Awarded August 2006
Thesis Title: 
“An Improved Method for Predicting LogP”
Advisor:  Robert Pearlman (Pharmaceutics)

2003              
Raed Khashan - Degree Awarded 12/03
Thesis Title:
  “Refinement and Validation of BCUT Descriptors for Computer-Assisted Drug Delivery”
Advisor:  Robert Pearlman (Pharmaceutics)

2001
Bobby Troung
- Degree awarded 8/01
Thesis Title:   "Development of an Insulin Pressurized Meter Dose Inhaler for Pulmonary Drug Delivery by Spray-Freezing into Cryogenic Vapor"
Advisor:  Robert O. Williams (U.T.A. Pharmaceutics)


Other Student Supervision

College of Pharmacy Honors Students


2022
James Sagun
Project:
“Aseptic Production and Sterility Testing of Thin Films”

2019-2022
Raquel Khanoyan
Project:
“An Evaluation of Global Environmental Conditions and Solutions for Distribution of Vaccines”

2018-2019
Valerie Yuenger
Project:
“Effect of Processing on Moisture Content of Novel Thin Films”

2018-2021
Isabella Chen
Project:
“Impact of Zwitterionic Surfactants on Viral Stability in Films”

2016-2018
Jocelyne Tientcheu
Project: 
“An Evaluation of Loading Efficiency of Protein in Thin Dissolvable Films”

2015-2018
Christine Hayeun Park

Project:  “Impact of Flavoring Agents on the Physical Properties of Dissolvable Films Used for Delivery of Vaccines via the Buccal Mucosa"

2014-2017
Lilian Q. Tran
Project:
  “Critical Evaluation of Serum Blood Chemistry and Cell Counts ofImmunized Non-Human Primates After Exposure to Ebola Zaire”

2014-2016
Jason X. Xu
Project: 
“Validation of a Real Time PCR Assay to Detect Virus Genomes in Biological Samples Collected After Administration of a Mucosal Vaccine for Ebola in Non-Human Primates”
Jason received an award for outstanding work by a Pharm.D. student at the 2015 College of Pharmacy Celebration of Research Day event.
Current Position: Jason is a Clinical Research Pharmacist at M.D. Anderson in Houston, TX.

2013-2016
Mark Myers
Project: 
“Pre-Clinical Evaluation of the Toxicology of Two Mucosal Vaccines for Ebola”  
Mark received an award for outstanding work by a Pharm.D. student at the 2014 College of Pharmacy Celebration of Research Day event.
Current Position: Mark is a Clinical Pharmacist at the VA Central California Health System in Fresno, California.

2009-2010
Samaneh Pourali
Project:
  “Effect of Novel β-D-maltopyranosides to Preserve Adenovirus Structure and Infectivity during Actuation from Two Nasal Spray Delivery Devices and During Long-Term Storage at Several Temperatures”

2009-2010
Tiffany Putache
Project:
  “Nasal Formulations for Long-Term Storage of a Liquid Virus-Based Vaccine”

2005-2008
Andrew Faso
Project:
  “Assessment of residual poly(ethylene) glycol in PEGylated Adenovirus Preparations and Identification of Modified Viral Proteins using a Colorimetric Assay and Polyacrylamide Gel Electrophoresis”
Current Position:  Andrew is a Clinical Pharmacist at Parkland Hospital in Dallas, TX.

2002-2003
Kelly Red
Project:
  “Effects of Adenoviral Infection on Renal Cytochrome P450 Protein Expression”
Current Position:  Kelly was pursuing a graduate degree in public health..

College of Pharmacy Hispanic Center of Excellence Multicultural Health Research Program

2007-2009
Sandra Renteria
Project:
  “Physical Characterization of Formulations for Nasal Delivery of Vaccines”
Sandra was first author of a peer-reviewed manuscript summarizing her work.
Current Position:  Sandra is a clinical pharmacist in El Paso, TX.

2006
John Andrade
Project: 
“Pharmacologic and Pharmacokinetic Studies of Docetaxel Alone and in Combination with Recombinant Adenovirus in Sprague Dawley Rats”
Current Position:  John is currently a Clinical Pharmacist at the University Medical Center of El Paso.

2004-2005
Kristina Gonzalez
Project: 
“Evaluation of Carprofen as a Effective Analgesic During Surgical Cannulation of Sprague Dawley Rats that Does Not Alter Hepatic Cytochrome P450 ”

2004
Selina Aguilar
Project:
  “Riboflavin: An Effective Agent for Controlled Inactivation of Recombinant Adenovirus for Analytical and Biological Use”
Current Position:  Selina is currently a Clinical Assistant Professor at the University of Texas at El Paso in the Cooperative Pharmacy Program

Special Projects Students - College of Pharmacy

2013
Staci Warren
Project:
  "Validation of an In Vitro Screening Method to Assess Potency of Adenovirus Based Vaccines"

2002-2003
Harsha Mistry
Project:
  "Effect of Polymer Size on the Pharmacokinetic Profiles of PEGylated Adenoviruses"
Current Position:  Harsha is a Clinical Pharmacist in the Clinical Programs and Strategy/IHSE Comprehensive Health Solutions Group at WellPoint, Inc.

College of Pharmacy - PharmD P4 Research Internship Rotations

2012
Ross Phan                          
Research Methods in Pharmaceutics
   
Project:  “Validation of Techniques to Evaluate the Potency of Buccal Vaccines”

2010
Michael Scott
Research Methods in Pharmaceutics    
Project:
  “Validation of the TR146 Cell Line as an In Vitro Model of the Buccal Mucosa”

2001-2002
Kayla Quick
Problems Course and Research Methods in Pharmaceutics
Project:
  “Aggregation Phenomena of a First-Generation and a Helper Dependent Adenovirus for use in Gene Delivery”
Kayla received The University of Texas College of Pharmacy Award for Outstanding Research in the Basic Sciences at the annual graduation ceremonies in 2002 in recognition of her research on adenovirus aggregation characteristics.  
Current Position:  Kayla is currently working as a Clinical pharmacist at the Children’s Medical Center in Dallas, TX.

U.T. College of Natural Sciences Honors / Plan II Honors Students

2019-21
Nicholas Cerda
UT College of Natural Sciences Deans Scholars Program
Project: 
“Intrinsically Disordered Proteins and Regions in Viruses: A Potential Use in Pharmaceuticals?”
Nicholas participated in a prestigious summer internship at The National Institutes of Health’s Rocky Mountain Labs, Hamilton, MT and was a Dean’s Honored Graduate for the 2020-2021 year.
Current Position: He is currently in the University of Pennsylvania Gene Therapy and Vaccines Ph.D. Program in the laboratory of Drew Weissman.

2012-2014
Brittney Boles
UT Biochemistry Undergraduate Honors Program
Project:
  “Physical and Biological Characteristics of Novel Formulations for a Rapid Release Bacteria-Based Vaccine”
Current Position:  Brittney started medical school in the fall semester of 2014 at the University of Texas Health Science Center in Houston, TX.

2011-2013
Kimberly Jones-Evans
UT Plan II Honors Program
Project: 
“Development of a Short Technical Course for Undergraduate and Professional Students Interested in Translational Research” and “Critical Analysis of Methodology for Prediction of and Response to Outbreaks of Dangerous Pathogens”
Kimberly joined the Croyle Lab in the summer of 2011 on a project to develop a technical training course for students interested in participating in translational research but have minimal exposure to basic laboratory techniques.  While in the field-testing phase of this project, she developed another idea which served as her senior thesis for the Plan II Honors program.  This involved a critical evaluation of current methods to predict and track outbreaks and spread of dangerous pathogens like Ebola and Dengue.  
Kimberly’s Thesis was selected as one of the Plan II Model Thesis for the Class of 2013.  
Current Position: Kimberly started her first year of medical school in the fall 2013 semester at the University of Texas Health Science Center in Houston, TX.

2009-2011
Albert Pai
UT College of Natural Sciences BS Option II
Project:
  “Development of an In Vitro System for Rapid Chemical and Physical Modification of Novel Vaccine Candidates Delivered by the Buccal Route”
Albert received a dual degree in biochemistry and math while doing research in the Croyle Lab.  He also spent the summer of 2010 at the Massachusetts Institute of Technology working on a project in bacterial genetics.

2007-2008
Elyor Sebbane
UT McNair Scholars Program
Project:
  “Assessment of the HB227 Cell Line as a Suitable In Vitro Model for Mechanistic Study of Changes in Intestinal Cytochrome P450 Expression and function During Viral Infection”
Elyor was awarded a competitive fellowship to support his summer research project based upon a proposal he constructed.  
Current Position: Elyor received a Master’s degree in Public Health under the advisement of Dr. David Katz at the Yale University School of Public Health .

2004-2006
Erin Clark
UT Biochemistry Undergraduate Honors Program
Project:
  “Characterization of T Cell Immunity Following Intranasal Immunization Against Ebola Virus”
Current Position: Erin was accepted in the Molecular and Cellular Biology Graduate Program at Harvard University, Fall 2006.  She is currently an instructor in the Biology Department at Northeastern University and a Postdoctoral Fellow in the laboratory of Dr. Sacha Nelson at Brandeis University.

Special Projects Students - U.T. Austin

2019
Alexander Karamyshev                                      
UT College of Natural Sciences
Project:
“Stability of Naked DNA in Thin Films”

2019-2020
Nicholas Cerda
UT College of Natural Sciences
Project:
“Tardigrade Proteins as Unique Stability Tools”

2018-2019
Madison Rex
UT Intellectual Entrepreneurship Program
Project:
“Effect of Excipients on Moisture Content of Films: Impact on Stability”
Madison received an award for outstanding work by an undergraduate student at the College of Pharmacy Celebration of Research Day event.

2017-2020
Seun Ibitoye
UT College of Natural Sciences
Project:
“Development of Novel Methods for Accurate Assessment of Dissolution of Thin Films”

2017-18        
Shadi Davanloo
UT College of Natural Sciences
Project:
“Changes in Protein and Expression of Cytochrome P450 Enzymes in HC-04 Cells with Respect to Passage Number”
Shadi was accepted in a Masters of Public Health program at Tufts University in the fall of 2018.

2015
Kimberly Brown
UT College of Natural Sciences
Project:
  “Changes in CYP3A4 Expression in the HC-04 Cell Line Over Time”

2014-2015
Irnela Bajrovic
UT Intellectual Entrepreneurship Program
Project:
  “Study of Virus Preservation in Sugary Glasses”
Irenla received an award for outstanding work by an undergraduate student at the College of Pharmacy Celebration of Research Day event.  She was accepted into the Pharmaceutics graduate program and will start her graduate work in the Croyle Lab in the Fall semester of 2015.

2014
Daniel Liaou
UT College of Natural Sciences
Project:
  “Role of Virus Infection on P-Glycoprotein Expression in the Liver”

2011-2013
Tejasvi Jaladi
UT College of Natural Sciences
Project:
  “Development of an In Vitro Screening Assay to Evaluate Vaccine Formulations for Capability to Bypass Pre-Existing Immunity to Adenovirus”
Current Position: Tejasvi will obtain a Masters degree in Chemical Engineering from Texas A &M University in the Spring of 2015.

2012
Teresa Kha-y Nguyen
UT College of Natural Sciences

Theresa spent one semester volunteering in the lab. She field-tested exercises included in the training program developed by Kimberly Evans.

2011-2012
Alessandria Ornelas
UT College of Natural Sciences
Project:
  “Role of pH During Processing and Development of Amorphous Solids Suitable for Immunization”
Alessandria graduated in May 2012 with a Bachelor’s degree in Microbiology.

2010
Emily Rosenfeld
UT College of Natural Sciences
Project:
  “Development of an In Vitro Plasmid-Based System to Determine the Molecular Mechanism of Viral Suppression of Hepatic Cytochrome P450”
Emily was considering a graduate career in immunology.

2010
Xuan Yue
UT College of Natural Sciences
Project:
  “Evaluation of Peptide Transporter Activity During Virus Infection”
Xuan was considering a graduate career in virology.

2009-2010
Nadia Khan
UT College of Natural Sciences
Project:
  “Role of Toll-Like Receptors in the Expression and Function of Hepatic CYP3A During Virus Infection”
Nadia was pre-med student interested in a career in research.  
She spent summer 2010 in a gene therapy lab at Stanford as an Amgen Scholar.
Current Position: She is currently a research assistant in Dr. Jude Samulski's lab at the University of North Carolina at Chapel Hill.

2009
Jobby John
UT College of Natural Sciences
Project:
  “Assessment of the Toxicity Associated with Novel Adenovirus-Based Vaccine Conjugates”  
Current Position: After completing a summer research project in the Croyle Lab, Jobby entered the UT Pharm.D. program.
Jobby is an author on a peer-reviewed manuscript for his contributions to one of the research projects in the Croyle Lab.
Current Position: Jobby completed the Pharm.D. program in 2013 and is currently co-owner of a newly built pharmacy, Lake Hills Pharmacy Compounding and Wellness Center in Bee Cave, Texas.

2009
Trenicia Olotu
UT College of Natural Sciences
Project:
  “Amplification of Genes that Regulate Expression of Hepatic CYP3A”
Current Position: Trenicia graduated in 2011 with a degree in forensic chemistry and is working as a research technician at Signature Science in Austin, TX.

2008
Katie Lee
UT Intellectual Entrepreneurship Program
Project:
  “Development of Methods to Rapidly Assess Long-Term Stability of Adenovirus-Based Vaccines”
Current Position: After completing the UTIE program, Katie was accepted in the UT Pharm.D. program and completed the professional program in 2013. 

2008
Evelyn Nash
Undergraduate Problems Course in Biology
Project:
  “Development of Novel Adenovirus Conjugates to Improve Oral Vaccine Potency”
Current Position: Ph.D. candidate in the laboratory of Mairi C. Noverr at LSU Health Sciences Center.

2008
Dennis Hu
Undergraduate Problems Course in Biochemistry
Project:
“Validation of a Bioassay to Assess the Potency of Adenovirus Vaccines”

2007-2008
Ian McCoy
UT College of Natural Sciences
Project:
“Characterization of novel methods for the production of AAV”
Current Position: Ian is currently attending medical school.

2007-2008
Courtney Clemens
UT Clinical Laboratory Medicine Program
Project:
  “Large Scale Production of an Ebola Virus Vaccine”
Current Position: After completing her degree at UT, Courtney was the Croyle Lab manager for one year.  She then became a certified medical technologist working at the University of Houston and entered medical school at the University of Texas Health Science Center in Houston in the fall of 2011.

2006
Pooja Patel
UT College of Natural Sciences
Project:
  “Molecular Reconstruction of Lentiviral Vectors”

2004
Matt Herpin
Undergraduate Problems Course in Biochemistry
Project:
  “Thermodynamic Properties of Adenovirus Capsid Proteins”
Current Position: Matt took a job in the pharmaceutical industry after graduating from UT.  He entered the Pharmaceutics graduate program at UT in the fall of 2010.

2003
Katie Gerding
UT College of Natural Sciences
Project:
  “Defined Media Requirements and Growth Characteristics of 293 Cells in Suspension Culture”
Katie worked in the Croyle Lab as a technician prior to entering the Pharm.D. program.  
Current Position: She is currently a Clinical Specialist in Internal Medicine at MD Anderson in Houston, TX.

2003-2004
Aida Alibegovic
UT College of Natural Sciences
Project:
  “Characterization of Release Profiles of PEGylated Adenovirus from PLGA Microspheres”
Current Position: Aida graduated with a degree in genetics and is currently working at Scripps Hospital (San Diego, CA) in the medical genetics department.

Special Projects Students from Other Universities

2018
Leah Selznick
Virginia Commonwealth University
Project:
“Evaluation of a Novel Thin Film Platform for the Stabilization of Poorly Water Soluble Drugs”
Leah was in the second year of the pharmacy professional program at VCU, interested in  global health and a career in academics which lead her to select our laboratory for a summer internship.

2009
Gavin Best
Duke University
Project:
  “Assessment of the Bio-distribution of Biochemically Modified Adenovirus-Based Vaccine Candidates for Ebola”
Gavin was a biochemistry major exploring a career in translational research.  
Current Position: Gavin is a research associate/lab manager in the laboratory of Anne Satterthwaite in the Department of Immunology at Southwestern Medical Center in Dallas, TX.

2005
Erin Hartman
California Institute of Technology
Project:
  “Assessment of Cytochrome P450 Gene Expression During Adenovirus Infection in Kidney Cell Lines”
Erin was a chemical engineering major who was awarded a competitive Summer Undergraduate Research Fellowship to work in the Croyle Lab.
Current Position: Erin received a Ph.D. in Political Science from UC Berkeley and was chief survey methodologist for the analytics department of Barack Obama’s 2012 re-election campaign. She also co-founded a company, BlueLabs, that uses data and technology to help progressive politicians.  In April 2015 Erin was listed in Pacific Standard’s “The 30 Top Thinkers Under 30” who is making a significant impact on current social, political, and economic issues in the United States.  

Pharm.D.-Ph.D./ Honors Program Exploratory Research Rotation Students

James Sagun                             Summer 2022
Matthew Sandoval                         Summer 2020
Trevor Sandoval                             Summer 2020
Byron Scott                                     Spring    2020
Raquel Khanoyan                            Fall         2019
Valerie Yuenger                               Spring    2018
Isabella Chen                                   Spring     2018
Steven Swank                                  Summer 2017
Brenda Astorga                                Summer 2017
Jocelyne Tientcheu             Summer 2016
Diana Sagirol                         Summer 2015
Jaynish Amin                         Summer 2015
Christine Park                       Summer 2015
Jason Xu                                  Summer 2014
Lilian Tran                              Summer 2014
Benjamin Casey                    Summer 2013
Mark Myers                            Summer 2013
Jae Seo Pi                                 Summer 2013
Grace I. Mbagwu                   Summer 2011
Hannah O’Mary                    Summer 2011
Greg Furman                          Spring 2011
Isaac Pan                                  Summer 2010
Omar Martinez                      Summer 2009
Heather Merrick                   Summer 2006
Brandon Patterson              Summer 2005

Research Rotation Students UT Cellular and Molecular Biology Graduate Program

Alex Klattenhoff                               Fall 2017
YuneSahng "Joseph" Hwang    Fall 2016
Kelly Michie                                     Fall 2014
Steven Castro                                  Summer 2013
Hiran Thyagarajan                         Summer 2012
Yongqiang Gou                               Spring 2011
An Li                                                Fall 2010
Robert Farris                                   Fall 2007
Jennifer Prowell                            Summer 2007
Alexis Smith                                    Fall 2006
Zhehiu (Jerry) Mao                        Fall 2006
Lin Winton                                       Spring 2006
Bomsoo Cho                                    Spring 2006
Joshua Cambridge                       Spring 2005
Supreet Singh                                Spring 2005
Xiaolei Li                                         Fall 2005            

Research Rotation Students M.D./Ph.D. Program UT and UTMB

Jay Truitt                                    Summer 2008

Updated:  August 10, 2023 by SCS